Version 5.4
Homo sapiens Protein: ESYT1
Summary
InnateDB Protein IDBP-39966.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ESYT1
Protein Name extended synaptotagmin-like protein 1
Synonyms FAM62A; MBC2;
Species Homo sapiens
Ensembl Protein ENSP00000267113
InnateDB Gene IDBG-39964 (ESYT1)
Protein Structure
UniProt Annotation
Function Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. {ECO:0000250, ECO:0000269PubMed:23791178, ECO:0000269PubMed:24183667}.
Subcellular Localization Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein. Note=Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:17360437}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0046872 metal ion binding
Biological Process
GO:0006869 lipid transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BSJ8
PhosphoSite PhosphoSite-Q9BSJ8
TrEMBL F8VZB1
UniProt Splice Variant
Entrez Gene 23344
UniGene Hs.632729
RefSeq NP_001171725
HUGO HGNC:29534
OMIM
CCDS CCDS53801
HPRD 14367
IMGT
EMBL AB018290 AC034102 AK025463 AK025878 AK290337 AL050134 BC004998 CH471054 DQ993200
GenPept AAH04998 ABJ97705 BAA34467 BAB15139 BAB15268 BAF83026 CAB43284 EAW96890 EAW96891 EAW96893

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca