InnateDB Protein
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IDBP-3999.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CMA1
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Protein Name
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chymase 1, mast cell
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Synonyms
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chymase; CYH; MCT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000250378
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InnateDB Gene
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IDBG-3997 (CMA1)
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Protein Structure
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Function |
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
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Subcellular Localization |
Secreted. Cytoplasmic granule. Note=Mast cell granules.
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Disease Associations |
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Tissue Specificity |
Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. {ECO:0000269PubMed:8144971}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
|
Protein-Protein |
15
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001254
Peptidase S1
IPR001314
Peptidase S1A, chymotrypsin-type
IPR009003
Trypsin-like cysteine/serine peptidase domain
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PFAM |
PF00089
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PRINTS |
PR00722
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PIRSF |
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SMART |
SM00020
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TIGRFAMs |
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Modification |
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SwissProt |
P23946
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PhosphoSite |
PhosphoSite-P23946
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TrEMBL |
Q4FEB5
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UniProt Splice Variant |
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Entrez Gene |
1215
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UniGene |
Hs.135626
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RefSeq |
NP_001827
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HUGO |
HGNC:2097
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OMIM |
118938
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CCDS |
CCDS9630
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HPRD |
00346
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IMGT |
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EMBL |
AB451464
AL132800
BC069110
BC069370
BC069490
BC103974
BC103975
CH471078
DQ082727
M64269
M69136
M69137
S61334
X59072
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GenPept |
AAA52019
AAA52020
AAA52021
AAB26828
AAH69110
AAH69370
AAH69490
AAI03975
AAI03976
AAZ06432
BAG70278
CAA41796
EAW66007
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