InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde4d

Summary

InnateDB Protein

IDBP-400637.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde4d

Protein Name

phosphodiesterase 4D, cAMP specific

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112991

InnateDB Gene

IDBG-181732 (Pde4d)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0030552	cAMP binding
GO:0031625	ubiquitin protein ligase binding
GO:0031698	beta-2 adrenergic receptor binding
GO:0046872	metal ion binding
GO:0051117	ATPase binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007568	aging
GO:0007613	memory
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0010469	regulation of receptor activity
GO:0010738	regulation of protein kinase A signaling
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030324	lung development
GO:0030593	neutrophil chemotaxis
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0032754	positive regulation of interleukin-5 production
GO:0035264	multicellular organism growth
GO:0043623	cellular protein complex assembly
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0061028	establishment of endothelial barrier
GO:0071222	cellular response to lipopolysaccharide
GO:0071320	cellular response to cAMP
GO:0071872	cellular response to epinephrine stimulus
GO:0071875	adrenergic receptor signaling pathway
GO:0086004	regulation of cardiac muscle cell contraction

Cellular Component

GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030016	myofibril
GO:0034704	calcium channel complex