Version 5.4
Mus musculus Protein: Fbxl5
Summary
InnateDB Protein IDBP-401015.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl5
Protein Name F-box and leucine-rich repeat protein 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000112444
InnateDB Gene IDBG-161237 (Fbxl5)
Protein Structure
UniProt Annotation
Function Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0055072 iron ion homeostasis
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2152883
InterPro IPR001611 Leucine-rich repeat
IPR001810 F-box domain
IPR006553 Leucine-rich repeat, cysteine-containing subtype
PFAM PF00560
PF13504
PF13855
PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
SM00367
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C2S5
PhosphoSite PhosphoSite-Q8C2S5
TrEMBL
UniProt Splice Variant
Entrez Gene 242960
UniGene Mm.457823
RefSeq
MGI ID
MGI Symbol Fbxl5
OMIM
CCDS
HPRD
IMGT
EMBL AK029957 AK041497 AK082931 AK085100 AK088067 AK150664 AK159744 AK171783 BC047214 BC113798
GenPept AAH47214 AAI13799 BAC26698 BAC30964 BAC38698 BAC39366 BAC40126 BAE29748 BAE35337 BAE42662

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca