Version 5.4
Mus musculus Protein: Gata4
Summary
InnateDB Protein IDBP-401050.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gata4
Protein Name GATA binding protein 4
Synonyms Gata-4;
Species Mus musculus
Ensembl Protein ENSMUSP00000113451
InnateDB Gene IDBG-172452 (Gata4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 34 [view]
Protein-DNA 13 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0001158 enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0033613 activating transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0051525 NFAT protein binding
GO:0070410 co-SMAD binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001706 endoderm formation
GO:0003181 atrioventricular valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003229 ventricular cardiac muscle tissue development
GO:0003290 atrial septum secundum morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007267 cell-cell signaling
GO:0007283 spermatogenesis
GO:0007507 heart development
GO:0009612 response to mechanical stimulus
GO:0010468 regulation of gene expression
GO:0010507 negative regulation of autophagy
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0035050 embryonic heart tube development
GO:0035054 embryonic heart tube anterior/posterior pattern specification
GO:0035239 tube morphogenesis
GO:0042493 response to drug
GO:0043627 response to estrogen
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048557 embryonic digestive tract morphogenesis
GO:0048598 embryonic morphogenesis
GO:0048617 embryonic foregut morphogenesis
GO:0048738 cardiac muscle tissue development
GO:0055007 cardiac muscle cell differentiation
GO:0060008 Sertoli cell differentiation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060070 canonical Wnt signaling pathway
GO:0060395 SMAD protein signal transduction
GO:0060464 lung lobe formation
GO:0060575 intestinal epithelial cell differentiation
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0071333 cellular response to glucose stimulus
GO:0071371 cellular response to gonadotropin stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0072148 epithelial cell fate commitment
GO:0072520 seminiferous tubule development
GO:0086004 regulation of cardiac muscle cell contraction
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:95664
InterPro IPR000679 Zinc finger, GATA-type
PFAM PF00320
PRINTS PR00619
PIRSF
SMART SM00401
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3UYJ1
UniProt Splice Variant
Entrez Gene 14463
UniGene Mm.247669
RefSeq
MGI ID
MGI Symbol Gata4
OMIM
CCDS
HPRD
IMGT
EMBL AC090654 AC090962 AK134639
GenPept BAE22221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca