InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plekha8

Summary

InnateDB Protein

IDBP-401251.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plekha8

Protein Name

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112466

InnateDB Gene

IDBG-149079 (Plekha8)

Protein Structure

UniProt Annotation

Function

Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4- phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Mainly localized to the trans-Golgi network (TGN) but also found at the rims of Golgi cisternae. Associates with ARF1 at Golgi apparatus membranes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017089	glycolipid transporter activity
GO:0051861	glycolipid binding
GO:0070273	phosphatidylinositol-4-phosphate binding
GO:0097001	ceramide binding