InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbrg1

Summary

InnateDB Protein

IDBP-401385.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbrg1

Protein Name

transforming growth factor beta regulated gene 1

Synonyms

AA408552; AA409675; mFLJ00213; Niam; Tb-5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112600

InnateDB Gene

IDBG-150806 (Tbrg1)

Protein Structure

UniProt Annotation

Function

Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. {ECO:0000269PubMed:17110379}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17110379}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006260	DNA replication
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0032066	nucleolus to nucleoplasm transport
GO:0050821	protein stabilization