InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mfn1

Summary

InnateDB Protein

IDBP-401601.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mfn1

Protein Name

mitofusin 1

Synonyms

2310002F04Rik; 6330416C07Rik; D3Ertd265e; HR2; mKIAA4032;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113251

InnateDB Gene

IDBG-136722 (Mfn1)

Protein Structure

UniProt Annotation

Function

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. {ECO:0000269PubMed:12527753, ECO:0000269PubMed:15297672}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11950885}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007275	multicellular organismal development
GO:0008053	mitochondrial fusion
GO:0045087	innate immune response (InnateDB)