InnateDB Protein
|
IDBP-40247.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SF3B3
|
Protein Name
|
splicing factor 3b, subunit 3, 130kDa
|
Synonyms
|
RSE1; SAP130; SF3b130; STAF130;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000305790
|
InnateDB Gene
|
IDBG-40245 (SF3B3)
|
Protein Structure
|
|
Function |
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:11564863}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 167 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
167
[view]
|
Protein-Protein |
167
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR004871
Cleavage/polyadenylation specificity factor, A subunit, C-terminal
IPR017986
WD40-repeat-containing domain
|
PFAM |
PF03178
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q15393
|
PhosphoSite |
PhosphoSite-Q15393
|
TrEMBL |
J3QRB2
|
UniProt Splice Variant |
|
Entrez Gene |
23450
|
UniGene |
Hs.732929
|
RefSeq |
NP_036558
|
HUGO |
HGNC:10770
|
OMIM |
605592
|
CCDS |
CCDS10894
|
HPRD |
12027
|
IMGT |
|
EMBL |
AC106804
AJ001443
AK001297
AL110251
BC000463
BC003146
BC009780
BC068974
D13642
D87686
|
GenPept |
AAH00463
AAH03146
AAH09780
AAH68974
BAA02805
BAA32662
BAG50889
CAB53699
CAB56791
|
|
|