InnateDB Protein
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IDBP-40334.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL34
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Protein Name
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interleukin 34
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000288098
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InnateDB Gene
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IDBG-40332 (IL34)
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Protein Structure
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Function |
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. {ECO:0000269PubMed:18467591, ECO:0000269PubMed:20489731, ECO:0000269PubMed:20504948, ECO:0000269PubMed:20829061}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:18467591}.
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Disease Associations |
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Tissue Specificity |
Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon. {ECO:0000269PubMed:18467591}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR020415
Interleukin-34
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PFAM |
PF15036
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PRINTS |
PR01938
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ZMJ4
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PhosphoSite |
PhosphoSite-
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TrEMBL |
J3QQT3
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UniProt Splice Variant |
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Entrez Gene |
146433
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UniGene |
Hs.461214
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RefSeq |
NP_001166243
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HUGO |
HGNC:28529
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OMIM |
612081
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CCDS |
CCDS10895
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HPRD |
14582
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IMGT |
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EMBL |
AC020763
AC106804
AK172744
AK314913
BC029804
CH471241
EU599219
EU636994
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GenPept |
AAH29804
ACD13452
ACD13474
BAD18731
BAG37425
EAW51801
EAW51802
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