InnateDB Protein
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IDBP-40483.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VAC14
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Protein Name
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Vac14 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261776
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InnateDB Gene
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IDBG-40481 (VAC14)
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Protein Structure
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Function |
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269PubMed:15542851, ECO:0000269PubMed:17556371}.
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Subcellular Localization |
Endosome membrane {ECO:0000269PubMed:15542851, ECO:0000269PubMed:17556371}. Microsome membrane {ECO:0000250}. Note=Mainly associated with membranes of the late endocytic pathway.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:8611628}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000357
HEAT
IPR016024
Armadillo-type fold
IPR021841
Vacuolar protein 14 C-terminal Fig4-binding domain
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PFAM |
PF02985
PF11916
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q08AM6
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PhosphoSite |
PhosphoSite-Q08AM6
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TrEMBL |
Q9NTB8
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UniProt Splice Variant |
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Entrez Gene |
55697
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UniGene |
Hs.445061
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RefSeq |
NP_060522
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HUGO |
HGNC:25507
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OMIM |
604632
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CCDS |
CCDS10896
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HPRD |
07660
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IMGT |
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EMBL |
AC020763
AC027281
AK025479
AK056433
AK093941
AL137396
BC000536
BC007214
BC125108
BC125109
CR457343
U25801
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GenPept |
AAB03813
AAH00536
AAH07214
AAI25109
AAI25110
BAB15145
BAG51707
BAG52790
CAB70724
CAG33624
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