InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL2

Summary

InnateDB Protein

IDBP-40506.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL2

Protein Name

chemokine (C-C motif) ligand 2

Synonyms

GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF;

Species

Homo sapiens

Ensembl Protein

ENSP00000225831

InnateDB Gene

IDBG-40504 (CCL2)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	32 [view]
Protein-DNA	12 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004672	protein kinase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0031727	CCR2 chemokine receptor binding

Biological Process

GO:0000165	MAPK cascade
GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001912	positive regulation of leukocyte mediated cytotoxicity
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002523	leukocyte migration involved in inflammatory response
GO:0002548	monocyte chemotaxis
GO:0002687	positive regulation of leukocyte migration
GO:0002693	positive regulation of cellular extravasation
GO:0006468	protein phosphorylation
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007010	cytoskeleton organization
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007259	JAK-STAT cascade
GO:0007568	aging
GO:0008347	glial cell migration
GO:0008360	regulation of cell shape
GO:0009408	response to heat
GO:0009611	response to wounding
GO:0009612	response to mechanical stimulus
GO:0009617	response to bacterium
GO:0009887	organ morphogenesis
GO:0010332	response to gamma radiation
GO:0010574	regulation of vascular endothelial growth factor production
GO:0010759	positive regulation of macrophage chemotaxis
GO:0014823	response to activity
GO:0016525	negative regulation of angiogenesis
GO:0019079	viral genome replication
GO:0019221	cytokine-mediated signaling pathway
GO:0019725	cellular homeostasis
GO:0022409	positive regulation of cell-cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031100	organ regeneration
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032570	response to progesterone
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032869	cellular response to insulin stimulus
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033552	response to vitamin B3
GO:0034351	negative regulation of glial cell apoptotic process
GO:0035684	helper T cell extravasation
GO:0035690	cellular response to drug
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0036120	cellular response to platelet-derived growth factor stimulus
GO:0042493	response to drug
GO:0043200	response to amino acid
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0043615	astrocyte cell migration
GO:0044267	cellular protein metabolic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045785	positive regulation of cell adhesion
GO:0046677	response to antibiotic
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048246	macrophage chemotaxis
GO:0048247	lymphocyte chemotaxis
GO:0050806	positive regulation of synaptic transmission
GO:0050870	positive regulation of T cell activation
GO:0051384	response to glucocorticoid
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0060135	maternal process involved in female pregnancy
GO:0060137	maternal process involved in parturition
GO:0070098	chemokine-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:0071300	cellular response to retinoic acid
GO:0071318	cellular response to ATP
GO:0071346	cellular response to interferon-gamma
GO:0071347	cellular response to interleukin-1
GO:0071354	cellular response to interleukin-6
GO:0071356	cellular response to tumor necrosis factor
GO:0071402	cellular response to lipoprotein particle stimulus
GO:0071403	cellular response to high density lipoprotein particle stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071549	cellular response to dexamethasone stimulus
GO:0090026	positive regulation of monocyte chemotaxis
GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages
GO:0090280	positive regulation of calcium ion import
GO:2000427	positive regulation of apoptotic cell clearance
GO:2000502	negative regulation of natural killer cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0030139	endocytic vesicle
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0043679	axon terminus
GO:0044299	C-fiber
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm