InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP10

Summary

InnateDB Protein

IDBP-40528.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP10

Protein Name

Rho GTPase activating protein 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000336923

InnateDB Gene

IDBG-40526 (ARHGAP10)

Protein Structure

UniProt Annotation

Function

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Association to cell membrane is dependent on PH domain. {ECO:0000250}.

Disease Associations

Tissue Specificity

High levels of expression in heart and skeletal muscle. {ECO:0000269PubMed:11432776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR011511 Variant SH3 domain

PFAM

PF00620
PF00018
PF14604
PF00169
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00324
SM00326
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt