InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAN2

Summary

InnateDB Protein

IDBP-40748.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAN2

Protein Name

PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

Synonyms

USP52;

Species

Homo sapiens

Ensembl Protein

ENSP00000257931

InnateDB Gene

IDBG-40746 (PAN2)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. {ECO:0000255HAMAP-Rule:MF_03182, ECO:0000269PubMed:14583602, ECO:0000269PubMed:16284618}.

Subcellular Localization

Cytoplasm, P-body. Nucleus. Note=Shuttles between nucleus and cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 344 experimentally validated interaction(s) in this database.

Experimentally validated
Total	344 [view]
Protein-Protein	343 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005829	cytosol
GO:0031251	PAN complex

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR006055 Exonuclease
IPR012337 Ribonuclease H-like domain
IPR013520 Exonuclease, RNase T/DNA polymerase III
IPR017986 WD40-repeat-containing domain
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain

PFAM

PF00443
PF00929

PRINTS

PIRSF

SMART

SM00479

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q504Q3