InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL1

Summary

InnateDB Protein

IDBP-40786.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL1

Protein Name

chemokine (C-C motif) ligand 1

Synonyms

I-309; P500; SCYA1; SISe; TCA3;

Species

Homo sapiens

Ensembl Protein

ENSP00000225842

InnateDB Gene

IDBG-40784 (CCL1)

Protein Structure

UniProt Annotation

Function

Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. {ECO:0000269PubMed:1557400}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007165	signal transduction
GO:0016032	viral process
GO:0045087	innate immune response (InnateDB)
GO:0060326	cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001811 Chemokine interleukin-8-like domain

PFAM

PF00048

PRINTS

PIRSF

SMART

SM00199

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P22362

PhosphoSite

PhosphoSite-

TrEMBL

Q76BR7

UniProt Splice Variant

Entrez Gene

6346

UniGene

Hs.72918

RefSeq

NP_002972

HUGO

HGNC:10609

OMIM

182281

CCDS

CCDS11282

HPRD

01654

IMGT

EMBL

AB110829 AK312183 BC105073 BC105075 CH471147 M57502 M57506

GenPept

AAA52705 AAA61196 AAI05074 AAI05076 BAC98367 BAG35116 EAW80204