InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGM3

Summary

InnateDB Protein

IDBP-41097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGM3

Protein Name

transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)

Synonyms

TGE;

Species

Homo sapiens

Ensembl Protein

ENSP00000370867

InnateDB Gene

IDBG-41095 (TGM3)

Protein Structure

UniProt Annotation

Function

Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003810	protein-glutamine gamma-glutamyltransferase activity
GO:0003824	catalytic activity
GO:0005509	calcium ion binding
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006464	cellular protein modification process
GO:0018149	peptide cross-linking
GO:0030216	keratinocyte differentiation
GO:0031069	hair follicle morphogenesis
GO:0031424	keratinization
GO:0043163	cell envelope organization
GO:0051262	protein tetramerization