Version 5.4
Homo sapiens Protein: AMBRA1
Summary
InnateDB Protein IDBP-41759.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMBRA1
Protein Name autophagy/beclin-1 regulator 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000318313
InnateDB Gene IDBG-41755 (AMBRA1)
Protein Structure
UniProt Annotation
Function Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005930 axoneme
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9C0C7
PhosphoSite PhosphoSite-Q9C0C7
TrEMBL E9PL55
UniProt Splice Variant
Entrez Gene 55626
UniGene Hs.738748
RefSeq NP_060219
HUGO HGNC:25990
OMIM 611359
CCDS CCDS31475
HPRD 10975
IMGT
EMBL AB051523 AC024293 AC115097 AC116021 AC127035 AK000301 AK023197 AL834190 BC045609 CH471064 DQ870924
GenPept AAH45609 ABI74670 BAA91067 BAB14457 BAB21827 EAW67996 EAW67999 EAW68001

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca