InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MC4R

Summary

InnateDB Protein

IDBP-4177.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MC4R

Protein Name

melanocortin 4 receptor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000299766

InnateDB Gene

IDBG-4175 (MC4R)

Protein Structure

UniProt Annotation

Function

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). {ECO:0000269PubMed:12646665}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269PubMed:10199800, ECO:0000269PubMed:11443223, ECO:0000269PubMed:11487744, ECO:0000269PubMed:12588803, ECO:0000269PubMed:12646665, ECO:0000269PubMed:14671178, ECO:0000269PubMed:14764818, ECO:0000269PubMed:15486053}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Brain, placental, and gut tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0031625	ubiquitin protein ligase binding
GO:0042923	neuropeptide binding

Biological Process

GO:0002024	diet induced thermogenesis
GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007631	feeding behavior
GO:0019222	regulation of metabolic process
GO:0030073	insulin secretion
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032868	response to insulin
GO:0045780	positive regulation of bone resorption
GO:0060259	regulation of feeding behavior
GO:2000252	negative regulation of feeding behavior
GO:2000821	regulation of grooming behavior

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000155 Melanocortin 4 receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001671 Melanocortin/ACTH receptor
IPR001908 Melanocortin receptor
IPR002230 Cannabinoid receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR01062
PR00237
PR00534
PR00535
PR00362

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32245