InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STS

Summary

InnateDB Protein

IDBP-41984.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STS

Protein Name

steroid sulfatase (microsomal), isozyme S

Synonyms

ARSC; ARSC1; ASC; ES; SSDD; XLI;

Species

Homo sapiens

Ensembl Protein

ENSP00000217961

InnateDB Gene

IDBG-41982 (STS)

Protein Structure

UniProt Annotation

Function

Conversion of sulfated steroid precursors to estrogens during pregnancy.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Ichthyosis, X-linked (IXL) [MIM:308100]: A keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. {ECO:0000269PubMed:10679952, ECO:0000269PubMed:10844566, ECO:0000269PubMed:1539590, ECO:0000269PubMed:9252398}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004773	steryl-sulfatase activity
GO:0008484	sulfuric ester hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0006706	steroid catabolic process
GO:0007565	female pregnancy
GO:0008152	metabolic process
GO:0008544	epidermis development
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000917 Sulfatase
IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
IPR017850 Alkaline-phosphatase-like, core domain

PFAM

PF00884
PF01663

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08842

PhosphoSite