Version 5.4
Homo sapiens Protein: RGS9BP
Summary
InnateDB Protein IDBP-42266.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS9BP
Protein Name regulator of G protein signaling 9 binding protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000334134
InnateDB Gene IDBG-42264 (RGS9BP)
Protein Structure
UniProt Annotation
Function Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Disease Associations Prolonged electroretinal response suppression (PERRS) [MIM:608415]: Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones. {ECO:0000269PubMed:14702087}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007603 phototransduction, visible light
GO:0009968 negative regulation of signal transduction
GO:0016056 rhodopsin mediated signaling pathway
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0050908 detection of light stimulus involved in visual perception
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZS82
PhosphoSite PhosphoSite-Q6ZS82
TrEMBL
UniProt Splice Variant
Entrez Gene 388531
UniGene Hs.528491
RefSeq NP_997274
HUGO HGNC:30304
OMIM 607814
CCDS CCDS12424
HPRD 16991
IMGT
EMBL AK124499 AK127646
GenPept BAC85865 BAC87072

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca