InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRG

Summary

InnateDB Protein

IDBP-42526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRG

Protein Name

protein tyrosine phosphatase, receptor type, G

Synonyms

HPTPG; PTPG; R-PTP-GAMMA; RPTPG;

Species

Homo sapiens

Ensembl Protein

ENSP00000295874

InnateDB Gene

IDBG-42524 (PTPRG)

Protein Structure

UniProt Annotation

Function

Possesses tyrosine phosphatase activity. {ECO:0000269PubMed:19167335}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Found in a variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0042802	identical protein binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001148 Alpha carbonic anhydrase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00194
PF00041
PF01108

PRINTS

PR00700

PIRSF

SMART

SM00194
SM01057
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt