Homo sapiens Protein: INHBE
Summary
InnateDB Protein IDBP-42560.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INHBE
Protein Name inhibin, beta E
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000266646
InnateDB Gene IDBG-42558 (INHBE)
Protein Structure
UniProt Annotation
Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0008083 growth factor activity
Biological Process
GO:0040007 growth
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001111 Transforming growth factor-beta, N-terminal
IPR001318 Inhibin, beta C subunit
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine
PFAM PF00688
PF00019
PRINTS PR00672
PR00669
PIRSF
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58166
PhosphoSite PhosphoSite-P58166
TrEMBL
UniProt Splice Variant
Entrez Gene 83729
UniGene Hs.632713
RefSeq NP_113667
HUGO HGNC:24029
OMIM 612031
CCDS CCDS8939
HPRD 11047
IMGT
EMBL AF412024 AK075285 BC005161
GenPept AAH05161 AAN03682 BAC11521