Homo sapiens Protein: PPID | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-43004.5 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | PPID | ||||||||||||||||||||||||||
Protein Name | peptidylprolyl isomerase D | ||||||||||||||||||||||||||
Synonyms | CYP-40; CYPD; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000303754 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-43002 (PPID) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large- cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release. {ECO:0000269PubMed:11350175, ECO:0000269PubMed:18708059, ECO:0000269PubMed:19932913, ECO:0000269PubMed:21711559, ECO:0000269PubMed:22681779, ECO:0000269PubMed:23220213, ECO:0000269PubMed:9659917}. | ||||||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. | ||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||
Tissue Specificity | Widely expressed. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR001440
Tetratricopeptide TPR1 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain IPR013026 Tetratricopeptide repeat-containing domain IPR019734 Tetratricopeptide repeat IPR029000 Cyclophilin-like domain |
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PFAM |
PF00515
PF00160 PF13174 PF13176 PF13181 |
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PRINTS |
PR00153
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PIRSF | |||||||||||||||||||||||||||
SMART |
SM00028
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TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | Q08752 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q08752 | ||||||||||||||||||||||||||
TrEMBL | E5KN55 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 5481 | ||||||||||||||||||||||||||
UniGene | Hs.183958 | ||||||||||||||||||||||||||
RefSeq | NP_005029 | ||||||||||||||||||||||||||
HUGO | HGNC:9257 | ||||||||||||||||||||||||||
OMIM | 601753 | ||||||||||||||||||||||||||
CCDS | CCDS3801 | ||||||||||||||||||||||||||
HPRD | 11875 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AK313929 AY714221 BC030707 CH471056 D63861 HQ205146 HQ205147 HQ205148 HQ205149 HQ205151 HQ205152 HQ205153 HQ205154 HQ205155 HQ205156 HQ205157 HQ205158 HQ205159 HQ205160 HQ205161 HQ205162 HQ205163 HQ205165 HQ205166 HQ205168 HQ205169 HQ205170 HQ205171 HQ205172 HQ205173 HQ205174 HQ205175 HQ205176 HQ205177 HQ205178 HQ205179 HQ205180 HQ205181 HQ205182 HQ205183 HQ205184 HQ205185 L11667 | ||||||||||||||||||||||||||
GenPept | AAA35731 AAH30707 AAT97986 ADP90614 ADP90615 ADP90616 ADP90617 ADP90619 ADP90620 ADP90621 ADP90622 ADP90623 ADP90624 ADP90625 ADP90626 ADP90627 ADP90628 ADP90629 ADP90630 ADP90631 ADP90633 ADP90634 ADP90636 ADP90637 ADP90638 ADP90639 ADP90640 ADP90641 ADP90642 ADP90643 ADP90644 ADP90645 ADP90646 ADP90647 ADP90648 ADP90649 ADP90650 ADP90651 ADP90652 ADP90653 BAA09923 BAG36649 EAX04853 | ||||||||||||||||||||||||||