InnateDB Protein
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IDBP-43110.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SEPT8
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Protein Name
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septin 8
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Synonyms
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SEP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000296873
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InnateDB Gene
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IDBG-43102 (SEPT8)
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Protein Structure
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Function |
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. {ECO:0000250, ECO:0000269PubMed:15116257, ECO:0000305}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In platelets, found in areas surrounding alpha-granules. {ECO:0000269PubMed:15116257}.
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Disease Associations |
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Tissue Specificity |
Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. {ECO:0000269PubMed:12023038, ECO:0000269PubMed:12909369, ECO:0000269PubMed:15116257, ECO:0000269PubMed:15915442}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000038
Cell division protein GTP binding
IPR016491
Septin
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00735
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PRINTS |
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PIRSF |
PIRSF006698
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q92599
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PhosphoSite |
PhosphoSite-Q92599
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TrEMBL |
C9J4G8
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UniProt Splice Variant |
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Entrez Gene |
23176
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UniGene |
Hs.593258
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RefSeq |
NP_055961
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HUGO |
HGNC:16511
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OMIM |
608418
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CCDS |
CCDS43360
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HPRD |
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IMGT |
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EMBL |
AC004775
AF179995
AF440761
AF440762
AF440763
AK057797
BC001329
CH471062
D86957
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GenPept |
AAG09407
AAH01329
AAO13878
AAO13879
AAO13880
BAA13193
EAW62315
EAW62317
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