Version 5.4
Homo sapiens Protein: SEPT8
Summary
InnateDB Protein IDBP-43116.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPT8
Protein Name septin 8
Synonyms SEP2;
Species Homo sapiens
Ensembl Protein ENSP00000367971
InnateDB Gene IDBG-43102 (SEPT8)
Protein Structure
UniProt Annotation
Function Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. {ECO:0000250, ECO:0000269PubMed:15116257, ECO:0000305}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In platelets, found in areas surrounding alpha-granules. {ECO:0000269PubMed:15116257}.
Disease Associations
Tissue Specificity Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. {ECO:0000269PubMed:12023038, ECO:0000269PubMed:12909369, ECO:0000269PubMed:15116257, ECO:0000269PubMed:15915442}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0007049 cell cycle
Cellular Component
GO:0031105 septin complex
Protein Structure and Domains
PDB ID
InterPro IPR000038 Cell division protein GTP binding
IPR016491 Septin
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00735
PRINTS
PIRSF PIRSF006698
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92599
PhosphoSite PhosphoSite-Q92599
TrEMBL C9J4G8
UniProt Splice Variant
Entrez Gene 23176
UniGene Hs.593258
RefSeq
HUGO HGNC:16511
OMIM 608418
CCDS CCDS47262
HPRD
IMGT
EMBL AC004775 AF179995 AF440761 AF440762 AF440763 AK057797 BC001329 CH471062 D86957
GenPept AAG09407 AAH01329 AAO13878 AAO13879 AAO13880 BAA13193 EAW62315 EAW62317

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca