InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGGT2

Summary

InnateDB Protein

IDBP-43211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGGT2

Protein Name

UDP-glucose glycoprotein glucosyltransferase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365938

InnateDB Gene

IDBG-43209 (UGGT2)

Protein Structure

UniProt Annotation

Function

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:12913004}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255PROSITE-ProRule:PRU10138, ECO:0000269PubMed:12913004}.

Disease Associations

Tissue Specificity

Higher levels in kidney, pancreas, heart, and skeletal muscle. {ECO:0000269PubMed:10694380}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003980	UDP-glucose:glycoprotein glucosyltransferase activity
GO:0016757	transferase activity, transferring glycosyl groups

Biological Process

GO:0006457	protein folding
GO:0006486	protein glycosylation
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0097359	UDP-glucosylation