InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FXYD3

Summary

InnateDB Protein

IDBP-43499.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FXYD3

Protein Name

FXYD domain containing ion transport regulator 3

Synonyms

MAT8; PLML;

Species

Homo sapiens

Ensembl Protein

ENSP00000339499

InnateDB Gene

IDBG-43497 (FXYD3)

Protein Structure

UniProt Annotation

Function

Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in a subset of human breast tumors.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005254	chloride channel activity

Biological Process

GO:0006811	ion transport
GO:0006821	chloride transport
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0034707	chloride channel complex
GO:0070062	extracellular vesicular exosome