InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDUFS3

Summary

InnateDB Protein

IDBP-43613.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFS3

Protein Name

NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)

Synonyms

CI-30;

Species

Homo sapiens

Ensembl Protein

ENSP00000263774

InnateDB Gene

IDBG-239864 (NDUFS3)

Protein Structure

UniProt Annotation

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	36 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0021762	substantia nigra development
GO:0022904	respiratory electron transport chain
GO:0030308	negative regulation of cell growth
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0031966	mitochondrial membrane