Version 5.4
Homo sapiens Protein: HS6ST3
Summary
InnateDB Protein IDBP-43638.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HS6ST3
Protein Name heparan sulfate 6-O-sulfotransferase 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365895
InnateDB Gene IDBG-43636 (HS6ST3)
Protein Structure
UniProt Annotation
Function 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0017095 heparan sulfate 6-O-sulfotransferase activity
Biological Process
GO:0008152 metabolic process
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR005331 Sulfotransferase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF03567
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IZP7
PhosphoSite PhosphoSite-Q8IZP7
TrEMBL B3KX95
UniProt Splice Variant
Entrez Gene 266722
UniGene Hs.171001
RefSeq NP_703157
HUGO HGNC:19134
OMIM 609401
CCDS CCDS9481
HPRD 11030
IMGT
EMBL AF539426 AK126947 AL138816 AL158192 CR749677
GenPept AAN33062 BAG54407 CAH18468 CAH71574 CAI13709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca