InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USF2

Summary

InnateDB Protein

IDBP-43816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USF2

Protein Name

upstream transcription factor 2, c-fos interacting

Synonyms

bHLHb12; FIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000222305

InnateDB Gene

IDBG-43810 (USF2)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose
GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007595	lactation
GO:0019086	late viral transcription
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055088	lipid homeostasis