InnateDB Protein
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IDBP-44340.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAF1C
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Protein Name
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TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
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Synonyms
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MGC:39976; SL1; TAFI110; TAFI95;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000345305
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InnateDB Gene
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IDBG-44336 (TAF1C)
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Protein Structure
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Function |
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. {ECO:0000269PubMed:11250903, ECO:0000269PubMed:15970593}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
30
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006360
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transcription from RNA polymerase I promoter
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GO:0006361
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transcription initiation from RNA polymerase I promoter
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GO:0006362
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transcription elongation from RNA polymerase I promoter
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GO:0006363
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termination of RNA polymerase I transcription
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0010467
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gene expression
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Cellular Component |
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PDB ID |
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InterPro |
IPR017986
WD40-repeat-containing domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15572
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PhosphoSite |
PhosphoSite-Q15572
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TrEMBL |
H3BQZ8
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UniProt Splice Variant |
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Entrez Gene |
9013
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UniGene |
Hs.153022
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RefSeq |
NP_647610
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HUGO |
HGNC:11534
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OMIM |
604905
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CCDS |
CCDS45535
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HPRD |
05364
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IMGT |
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EMBL |
AB209594
AC009123
AK299060
AK299347
AK304261
AK315982
AY158985
BC028131
L39059
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GenPept |
AAA62861
AAH28131
AAN38818
BAD92831
BAH12941
BAH13010
BAH14144
BAH14353
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