Version 5.4
Homo sapiens Protein: WFDC1
Summary
InnateDB Protein IDBP-44554.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFDC1
Protein Name WAP four-disulfide core domain 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000219454
InnateDB Gene IDBG-44552 (WFDC1)
Protein Structure
UniProt Annotation
Function Has growth inhibitory activity. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0010951 negative regulation of endopeptidase activity
GO:0030308 negative regulation of cell growth
GO:0032355 response to estradiol
GO:0042493 response to drug
GO:0050680 negative regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR008197 Whey acidic protein-type 4-disulphide core
PFAM PF00095
PRINTS PR00003
PIRSF
SMART SM00217
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HC57
PhosphoSite PhosphoSite-Q9HC57
TrEMBL
UniProt Splice Variant
Entrez Gene 58189
UniGene Hs.36688
RefSeq NP_067020
HUGO HGNC:15466
OMIM 605322
CCDS CCDS10946
HPRD 05614
IMGT
EMBL AF169631 AF302109 AK075061 BC029159 CH471114
GenPept AAG15263 AAG16647 AAH29159 BAC11377 EAW95486 EAW95487

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca