InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP2C2

Summary

InnateDB Protein

IDBP-44578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2C2

Protein Name

ATPase, Ca++ transporting, type 2C, member 2

Synonyms

SPCA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262429

InnateDB Gene

IDBG-44576 (ATP2C2)

Protein Structure

UniProt Annotation

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0008152	metabolic process
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0000139	Golgi membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR006413 Calcium-transporting P-type ATPase, subfamily IIA, PMR1-type
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt