InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HMGB2

Summary

InnateDB Protein

IDBP-44659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGB2

Protein Name

high mobility group box 2

Synonyms

HMG2;

Species

Homo sapiens

Ensembl Protein

ENSP00000296503

InnateDB Gene

IDBG-44657 (HMGB2)

Protein Structure

UniProt Annotation

Function

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0019904	protein domain specific binding
GO:0042056	chemoattractant activity
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006265	DNA topological change
GO:0006288	base-excision repair, DNA ligation
GO:0006309	apoptotic DNA fragmentation
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0007283	spermatogenesis
GO:0007289	spermatid nucleus differentiation
GO:0008584	male gonad development
GO:0032075	positive regulation of nuclease activity
GO:0033151	V(D)J recombination
GO:0043388	positive regulation of DNA binding
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048545	response to steroid hormone
GO:0050918	positive chemotaxis
GO:0051103	DNA ligation involved in DNA repair
GO:0060326	cell chemotaxis
GO:0071222	cellular response to lipopolysaccharide
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0000793	condensed chromosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm