InnateDB Protein
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IDBP-44683.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COTL1
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Protein Name
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coactosin-like 1 (Dictyostelium)
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Synonyms
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CLP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262428
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InnateDB Gene
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IDBG-44681 (COTL1)
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Protein Structure
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Function |
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269PubMed:11583571, ECO:0000269PubMed:19807693}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus membrane; Peripheral membrane protein.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. {ECO:0000269PubMed:11583571}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002108
Actin-depolymerising factor homology domain
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PFAM |
PF00241
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PRINTS |
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PIRSF |
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SMART |
SM00102
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TIGRFAMs |
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Modification |
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SwissProt |
Q14019
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PhosphoSite |
PhosphoSite-Q14019
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TrEMBL |
H3BT58
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UniProt Splice Variant |
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Entrez Gene |
23406
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UniGene |
Hs.710668
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RefSeq |
NP_066972
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HUGO |
HGNC:18304
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OMIM |
606748
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CCDS |
CCDS10947
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HPRD |
09482
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IMGT |
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EMBL |
AC022165
AC092145
AK315675
BC010039
BC010884
BC016702
BC042970
BC053682
BT006968
CH471114
L54057
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GenPept |
AAA88022
AAH10039
AAH10884
AAH16702
AAH42970
AAH53682
AAP35614
BAG38040
EAW95476
EAW95477
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