InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SAP30

Summary

InnateDB Protein

IDBP-44692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAP30

Protein Name

Sin3A-associated protein, 30kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296504

InnateDB Gene

IDBG-44690 (SAP30)

Protein Structure

UniProt Annotation

Function

Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. {ECO:0000250UniProtKB:O88574, ECO:0000269PubMed:9651585}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney. {ECO:0000269PubMed:9702189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	49 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0035914	skeletal muscle cell differentiation