Version 5.4
Homo sapiens Protein: IDI1
Summary
InnateDB Protein IDBP-45036.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDI1
Protein Name isopentenyl-diphosphate delta isomerase 1
Synonyms IPP1; IPPI1;
Species Homo sapiens
Ensembl Protein ENSP00000370748
InnateDB Gene IDBG-45034 (IDI1)
Protein Structure
UniProt Annotation
Function Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). {ECO:0000269PubMed:8806705}.
Subcellular Localization Peroxisome.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004452 isopentenyl-diphosphate delta-isomerase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0035634 response to stilbenoid
GO:0044281 small molecule metabolic process
GO:0050992 dimethylallyl diphosphate biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000086 NUDIX hydrolase domain
IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1
IPR015797 NUDIX hydrolase domain-like
PFAM PF00293
PRINTS
PIRSF PIRSF018427
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13907
PhosphoSite PhosphoSite-Q13907
TrEMBL C9JKM8
UniProt Splice Variant
Entrez Gene 3422
UniGene
RefSeq NP_004499
HUGO HGNC:5387
OMIM 604055
CCDS CCDS7056
HPRD 07235
IMGT
EMBL AC022536 AF271720 AF271721 AF271722 AF271723 AF271724 AF291755 AK222875 AK303669 BC005247 BC006999 BC019227 BC022418 BC025375 BC057827 BC107893 BT006761 CH471072 X17025
GenPept AAH05247 AAH06999 AAH19227 AAH22418 AAH25375 AAH57827 AAI07894 AAK29357 AAK49434 AAK49435 AAP35407 BAD96595 BAG64667 CAA34890 EAW86521

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca