InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDZRN3

Summary

InnateDB Protein

IDBP-45042.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDZRN3

Protein Name

PDZ domain containing ring finger 3

Synonyms

LNX3; SEMACAP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000263666

InnateDB Gene

IDBG-45040 (PDZRN3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors. {ECO:0000269PubMed:10470851, ECO:0000269PubMed:15305371, ECO:0000269PubMed:17118964}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding