InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRSS1

Summary

InnateDB Protein

IDBP-45080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRSS1

Protein Name

protease, serine, 1 (trypsin 1)

Synonyms

TRP1; TRY1; TRY4; TRYP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000308720

InnateDB Gene

IDBG-45037 (PRSS1)

Protein Structure

UniProt Annotation

Function

Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates. {ECO:0000269PubMed:7945238}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269PubMed:10204851, ECO:0000269PubMed:10381903, ECO:0000269PubMed:10930381, ECO:0000269PubMed:11073545, ECO:0000269PubMed:11788572, ECO:0000269PubMed:11866271, ECO:0000269PubMed:14695529, ECO:0000269PubMed:15776435, ECO:0000269PubMed:8841182, ECO:0000269PubMed:9322498, ECO:0000269PubMed:9633818}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0007586	digestion
GO:0009235	cobalamin metabolic process
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0044281	small molecule metabolic process