Homo sapiens Protein: KCNV2
Summary
InnateDB Protein IDBP-45137.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNV2
Protein Name potassium channel, subfamily V, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000371514
InnateDB Gene IDBG-45135 (KCNV2)
Protein Structure
UniProt Annotation
Function Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
Disease Associations Cone dystrophy retinal 3B (RCD3B) [MIM:610356]: A rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. {ECO:0000269PubMed:16909397}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon. {ECO:0000269PubMed:12060745}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005251 delayed rectifier potassium channel activity
Biological Process
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003971 Potassium channel, voltage dependent, Kv9
IPR003974 Potassium channel, voltage dependent, Kv3
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain
PFAM PF02214
PF00520
PF07885
PRINTS PR00169
PR01491
PR01494
PR01498
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDN2
PhosphoSite PhosphoSite-Q8TDN2
TrEMBL
UniProt Splice Variant
Entrez Gene 169522
UniGene Hs.622675
RefSeq NP_598004
HUGO HGNC:19698
OMIM 607604
CCDS CCDS6447
HPRD 12126
IMGT
EMBL AF348983 AL354723 BC101352 BC101353
GenPept AAI01353 AAI01354 AAL83910 CAI15124