InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC15A1

Summary

InnateDB Protein

IDBP-45190.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC15A1

Protein Name

solute carrier family 15 (oligopeptide transporter), member 1

Synonyms

HPECT1; HPEPT1; PEPT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000365686

InnateDB Gene

IDBG-45188 (SLC15A1)

Protein Structure

UniProt Annotation

Function

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0015198	oligopeptide transporter activity
GO:0015333	peptide:hydrogen symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006857	oligopeptide transport
GO:0007586	digestion
GO:0015031	protein transport
GO:0015992	proton transport
GO:0035672	oligopeptide transmembrane transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000109 Proton-dependent oligopeptide transporter family
IPR004768 Oligopeptide transporter
IPR016196 Major facilitator superfamily domain, general substrate transporter

PFAM

PF00854

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46059

PhosphoSite