Version 5.4
Homo sapiens Protein: STARD3
Summary
InnateDB Protein IDBP-45856.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STARD3
Protein Name StAR-related lipid transfer (START) domain containing 3
Synonyms CAB1; es64; MLN64;
Species Homo sapiens
Ensembl Protein ENSP00000337446
InnateDB Gene IDBG-45854 (STARD3)
Protein Structure
UniProt Annotation
Function Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain.
Subcellular Localization Late endosome membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0017127 cholesterol transporter activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006701 progesterone biosynthetic process
GO:0006839 mitochondrial transport
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0030301 cholesterol transport
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR000799 Steroidogenic acute regulatory protein, animal
IPR002913 START domain
IPR019498 MENTAL domain
PFAM PF01852
PF10457
PRINTS PR00978
PIRSF
SMART SM00234
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14849
PhosphoSite PhosphoSite-Q14849
TrEMBL J3QRG8
UniProt Splice Variant
Entrez Gene 10948
UniGene Hs.728838
RefSeq NP_006795
HUGO HGNC:17579
OMIM 607048
CCDS CCDS11341
HPRD 06132
IMGT
EMBL AC087491 AK123364 AK300176 AK300842 BC008356 BC008747 BC025679 BT006964 D38255 X80198
GenPept AAH08356 AAH08747 AAH25679 AAP35610 BAA22525 BAG53896 BAG61955 BAG62493 CAA56489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca