InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ING2

Summary

InnateDB Protein

IDBP-46022.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ING2

Protein Name

inhibitor of growth family, member 2

Synonyms

ING1L; p33ING2;

Species

Homo sapiens

Ensembl Protein

ENSP00000307183

InnateDB Gene

IDBG-46020 (ING2)

Protein Structure

UniProt Annotation

Function

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). {ECO:0000269PubMed:11481424, ECO:0000269PubMed:12859901}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12859901}. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.

Disease Associations

Tissue Specificity

Widely expressed. Higher expressed in colon- cancer tumor than in normal colon tissues. {ECO:0000269PubMed:10072587}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0032403	protein complex binding
GO:0035064	methylated histone binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007141	male meiosis I
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0008285	negative regulation of cell proliferation
GO:0016568	chromatin modification
GO:0030317	sperm motility
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0040008	regulation of growth
GO:0043065	positive regulation of apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048133	male germ-line stem cell division
GO:0072520	seminiferous tubule development
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000772	regulation of cellular senescence
GO:2001020	regulation of response to DNA damage stimulus
GO:2001234	negative regulation of apoptotic signaling pathway