InnateDB Protein
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IDBP-46125.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FIGF
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Protein Name
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c-fos induced growth factor (vascular endothelial growth factor D)
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Synonyms
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VEGF-D; VEGFD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000297904
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InnateDB Gene
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IDBG-46123 (FIGF)
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Protein Structure
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Function |
Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. {ECO:0000269PubMed:21148085}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000072
PDGF/VEGF domain
IPR029034
Cystine-knot cytokine
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PFAM |
PF00341
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PRINTS |
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PIRSF |
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SMART |
SM00141
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TIGRFAMs |
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Modification |
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SwissProt |
O43915
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
2277
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UniGene |
Hs.11392
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RefSeq |
NP_004460
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HUGO |
HGNC:3708
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OMIM |
300091
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CCDS |
CCDS14166
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HPRD |
02102
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IMGT |
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EMBL |
AJ000185
AK313173
BC027948
CH471074
D89630
Y12863
Y12864
Y12865
Y12866
Y12867
Y12868
Y12869
Y12870
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GenPept |
AAH27948
BAA24264
BAG35990
CAA03942
CAA73370
CAA73371
EAW98885
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