Version 5.4
Homo sapiens Protein: ALKBH6
Summary
InnateDB Protein IDBP-46160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALKBH6
Protein Name alkB, alkylation repair homolog 6 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000252984
InnateDB Gene IDBG-409328 (ALKBH6)
Protein Structure
UniProt Annotation
Function Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17979886}. Nucleus {ECO:0000269PubMed:17979886}.
Disease Associations
Tissue Specificity Widely expressed, with highest expression in testis and pancreas. {ECO:0000269PubMed:17979886}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0046872 metal ion binding
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
PFAM PF03171
PF13640
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3KRA9
PhosphoSite PhosphoSite-Q3KRA9
TrEMBL B2RAE0
UniProt Splice Variant
Entrez Gene 84964
UniGene
RefSeq NP_001284630
HUGO HGNC:28243
OMIM 613304
CCDS CCDS74342
HPRD 17510
IMGT
EMBL AB273714 AF038458 AK310704 AK314150 BC105801
GenPept AAI05802 BAF63844 BAG36837

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca