Version 5.4
Homo sapiens Protein: ATL2
Summary
InnateDB Protein IDBP-46172.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATL2
Protein Name atlastin GTPase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000368237
InnateDB Gene IDBG-46170 (ATL2)
Protein Structure
UniProt Annotation
Function GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. {ECO:0000269PubMed:18270207, ECO:0000269PubMed:19665976}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:18270207}; Multi-pass membrane protein {ECO:0000269PubMed:18270207}.
Disease Associations
Tissue Specificity Expressed in peripheral tissues (at protein level). {ECO:0000269PubMed:18270207}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042802 identical protein binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0051260 protein homooligomerization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF02841
PF02263
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHH9
PhosphoSite PhosphoSite-Q8NHH9
TrEMBL B7ZA64
UniProt Splice Variant
Entrez Gene 64225
UniGene Hs.727652
RefSeq NP_001129145
HUGO HGNC:24047
OMIM 609368
CCDS CCDS46260
HPRD 10662
IMGT
EMBL AC016995 AF449176 AF449177 AF449178 AF449179 AF449180 AF449181 AF449182 AF449183 AF449184 AF449185 AF449186 AF449187 AK026946 AK225190 AK294049 AK302621 AK316179 BC053508
GenPept AAH53508 AAM97341 AAM97342 AAX88950 BAB15598 BAH11658 BAH13764 BAH14550

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca