InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL17C

Summary

InnateDB Protein

IDBP-46306.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL17C

Protein Name

interleukin 17C

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000244241

InnateDB Gene

IDBG-46304 (IL17C)

Protein Structure

UniProt Annotation

Function

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. {ECO:0000269PubMed:21993848}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0030223	neutrophil differentiation
GO:0045087	innate immune response (InnateDB)
GO:1900017	positive regulation of cytokine production involved in inflammatory response