InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BMX

Summary

InnateDB Protein

IDBP-46346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMX

Protein Name

BMX non-receptor tyrosine kinase

Synonyms

ETK; PSCTK2; PSCTK3;

Species

Homo sapiens

Ensembl Protein

ENSP00000308774

InnateDB Gene

IDBG-46340 (BMX)

Protein Structure

UniProt Annotation

Function

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269PubMed:10688651, ECO:0000269PubMed:11331870, ECO:0000269PubMed:12370298, ECO:0000269PubMed:12832404, ECO:0000269PubMed:15788485, ECO:0000269PubMed:18292575, ECO:0000269PubMed:9520419}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1.

Disease Associations

Tissue Specificity

Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006950	response to stress
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007498	mesoderm development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005829	cytosol
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00017
PF14633
PF07714
PF00779
PF00169

PRINTS

PR00401
PR00109
PR00402

PIRSF

SMART

SM00252
SM00107
SM00233
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt