InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBCB

Summary

InnateDB Protein

IDBP-46533.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBCB

Protein Name

tubulin folding cofactor B

Synonyms

CG22; CKAP1; CKAPI;

Species

Homo sapiens

Ensembl Protein

ENSP00000221855

InnateDB Gene

IDBG-46531 (TBCB)

Protein Structure

UniProt Annotation

Function

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15831477}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15831477}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.

Disease Associations

Tissue Specificity

Found in most tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007399	nervous system development
GO:0030154	cell differentiation
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding