Version 5.4
Homo sapiens Protein: AK3
Summary
InnateDB Protein IDBP-46607.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AK3
Protein Name adenylate kinase 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000352948
InnateDB Gene IDBG-46603 (AK3)
Protein Structure
UniProt Annotation
Function Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {ECO:0000255HAMAP-Rule:MF_03169, ECO:0000269PubMed:11485571}.
Subcellular Localization Mitochondrion matrix {ECO:0000255HAMAP- Rule:MF_03169, ECO:0000269PubMed:11485571}.
Disease Associations
Tissue Specificity Highly expressed in heart, skeletal muscle and liver, moderately expressed in pancreas and kidney, and weakly expressed in placenta, brain and lung. {ECO:0000269PubMed:11485571}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004017 adenylate kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0046899 nucleoside triphosphate adenylate kinase activity
Biological Process
GO:0006172 ADP biosynthetic process
GO:0007596 blood coagulation
GO:0016310 phosphorylation
GO:0046033 AMP metabolic process
GO:0046039 GTP metabolic process
GO:0046041 ITP metabolic process
GO:0046051 UTP metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR000850 Adenylate kinase/UMP-CMP kinase
IPR007862 Adenylate kinase, active site lid domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF05191
PRINTS PR00094
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UIJ7
PhosphoSite PhosphoSite-Q9UIJ7
TrEMBL
UniProt Splice Variant
Entrez Gene 50808
UniGene Hs.732022
RefSeq NP_001186782
HUGO HGNC:17376
OMIM 609290
CCDS CCDS56561
HPRD 12439
IMGT
EMBL AB021870 AF183419 AK001553 AK001951 AK027534 AK098205 AK298200 AL136231 AL353151 BC013771 CH471071
GenPept AAG09688 AAH13771 BAA87913 BAA91753 BAA91996 BAB55183 BAG53592 BAG60470 CAH72282 CAH72283 CAI41260 CAI41262 EAW58779 EAW58780 EAW58781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca